Mpx - Vaccine

While there are two vaccines available in the U.S. to prevent Mpx (MPV), there is very little supply in Iowa. To best reach people who are at highest risk of MPV, we are working with a few local public health departments and health care providers that already care for people at highest risk for MPV disease to vaccinate their patients.


Providers are using the following strategies to use this limited vaccine:

  • Post-exposure prophylaxis (PEP): Provide vaccine to people who know they had an exposure to MPV.
  • PEP++: Provide vaccine to people who are at the highest risk for MPV, even if they don't know if they had an exposure to MPV.


  • Iowa’s allocation of the JYNNEOS vaccine is not sufficient to implement a statewide vaccination strategy which includes a large number of healthcare provider sites. Only select healthcare partners will serve as PEP++ providers in Iowa.
  • The amount of vaccine being provided to our state is only enough to vaccinate a few thousand people in Iowa. That means we need to prioritize people at highest risk for severe MPV disease and those most likely to have been recently in contact with someone with MPV.
  • More information regarding the state’s allocation of MPV vaccine can be found here.


PEP++ is for people with unconfirmed exposure to the virus but with risk factors that may make them more likely to get Mpx. Due to the high demand, and current supply shortages, the following are the current eligibility requirements to receive this vaccine.owans with the highest likelihood of exposure to Mpx MUST be prioritized to receive the vaccine. Data indicates most, but not all, cases occur among gay, bisexual, and other men who have sex with men.

  • PEP++ Eligibility:
    • Gay, bisexual, other men who have sex with men (MSM), or transgender people* and their partners
    • People living with HIV
    • People who report being at a venue in which a suspected, probable, or confirmed case of Mpx was identified
    • People who report having close contact with someone suspected, probable, or confirmed as having Mpx.

Vaccine Administration

  • To increase the number of people at risk that can be vaccinated, the CDC and FDA recommend adults 18 years of age or older who are at high risk for being exposed to the Mpx virus be vaccinated with a 0.1 mL dose of the JYNNEOS vaccine that is administered intradermally (between layers of skin) instead of subcutaneously (underneath the skin).
  • Administering the vaccine intradermally for adults 18 years of age or older is an important way to increase the number of people who can be vaccinated because of the lower dose used while still offering a high-level of protection as measured using similar methods.
  • The CDC does recommend that eligible individuals receive the JYNNEOS vaccine regardless of previous vaccine history.


  • When the vaccine is administered intradermally, it has been shown to produce nearly identical levels of antibody protection compared to a higher dose of the same vaccine administered subcutaneously (i.e., intramuscularly).
  • Intradermal administration has been effective for other types of vaccine including yellow fever, polio and rabies.

Iowa Mpx PEP++ Vaccination Sites

Black Hawk County

Black Hawk County Health Department

Cerro Gordo

Cerro Gordo County Health Department

Des Moines County

Des Moines County Health Department

  • Call to determine eligibility: 319-753-8290

Dubuque County

Dubuque Visiting Nurse Association

  • Call to determine eligibility: 563-556-6200

Johnson County

Johnson County Health Department

Linn County

Linn County Health Department

Polk County

Polk County Health Department

  • Schedule appointments:
  • Questions:  PCHD Call Center 515-323-5221
  • Appointment times August 8-12, 2022:
    • Mon-Wed-Fri:  12:30-4:30 PM
    • Tues-Thurs:  8:30 AM -12:30 PM
  • The health department only creates appointments if there is enough vaccine available;  if there are no appointments available, Jynneos vaccine is no longer available

Primary Health Care Outreach - University

Schedule appointments at: 515-248-1500 and through The Project at  515-248-1595       

Pottawattamie County

Pottawattamie County Health Department

  • Call to determine eligibility: 712-242-1155
    • All requests will be reviewed and individuals will receive a call back with an appointment time if eligible for vaccination
    • If there are no appointments available, website will be updated

Scott County

  • Scott County Health Department
    • Schedule Appointments and determine eligibility at: 563-326-8618
    • Callers should identify they are calling with questions regarding monkeypox
    • Eligible vaccine recipients will be offered same day access
      • Monday and Tuesday, Thursday and Friday from  8:15 am - 4:00 pm;
      • Appointments are REQUIRED

Webster County

Webster County Health Department

  • Call to determine eligibility: 515-573-4107

Woodbury County

Siouxland District Health Department